Two Diabetes Drug Mysteries
Here are some data to file under “Drugs do things that we don’t expect”. The SGLT-2 inhibitors are a class of diabetes medications that work by inhibiting the sodium/glucose transporter 2 protein in...
View ArticleHold On, Merck’s CETP Inhibitor Actually Works?
Well, maybe. I have to admit that my first reaction was disbelief. Merck has come out this morning with a statement that its long-running outcomes trial with anacetrapib, their cholesteryl ester...
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AMPK: Time To Think Hard
AMP-activated protein kinase, now that’s an enzyme for you. It sits at the center of a cell’s metabolic switchboard, and if you’re talking about anything to do with the response to levels of fuel like...
View ArticleInhaled Nanoparticles – Good Ones, That Is
Never give up on drug delivery ideas – that’s one of the big points I get out of this paper. The authors, part of a multi-center team from sites in Italy and Germany, have previously shown that calcium...
View ArticleA Run of Contrary Results
From the outside, medical progress looks a lot easier than it really is. Well, I realize that’s true of a lot of things, but it’s especially true in progress against disease, and that’s especially...
View ArticleMetformin and Exercise
I’ve written about metformin quite a few times over the years on the blog, and for several reasons. It is (for starters) obviously a frontline drug for treatment of Type 2 diabetes, a condition that...
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Angiotensin and the Coronavirus
There’s quite a bit of confusion around the ACE proteins and coronavirus infection, and I can see why. The names in this area are pretty confusing, for one thing, and if you’re not familiar with the...
View ArticleCovid-19, Blood Pressure Medication, and Ibuprofen
One of the questions that shows up often in the comments to the various Covid-19 posts here (especially this one) and very often in my own emails is whether people who are taking hypertension...
View ArticleAngiotensin and Coronavirus Infection: The Latest as of April 7
I wrote here the other day on the recent recommendation that people taking either ACE (angiotensin-converting enzyme) inhibitors or ARBs (angiotensin receptor blockers) should not alter their treatment...
View ArticleThe Latest Hydroxychloroquine Data, As of April 11
We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up. First off is an abstract from the Marseilles IHU group of Dr. Didier Raoult. It presents 1061 patients...
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